Sertraline Demonstrates Fungicidal Activity Against Coccidioides immitis In Vitro
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چکیده
منابع مشابه
Collagenolytic activity of Coccidioides immitis.
Coccidioides immitis appears to be unable to digest particulate collagen when cultured on collagen-containing semisolid culture media. However, all C. immitis strains solubilized collagen when the fungus was grown in liquid suspension cultures. Moreover, sterile culture filtrates were collagenolytic in collagen-buffer-agar plate assays.
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The in vitro growth of the spherule (sporangium) phase of Coccidioides immitis has posed a problem of prime interest in the study of the disease coccidioidomycosis. The fungus is dimorphic in that it has a cultural, or saprophytic, phase in which growth consists of mycelium and arthrospores, and a tissue or parasitic phase consisting of thick-walled nonbudding spherules (sporangia) varying in s...
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Posaconazole (SCH 56592) was tested against 25 strains of Coccidioides immitis to determine their in vitro susceptibilities. The geometric mean 48-h MIC of posaconazole (POSA) was 0.5 microg/ml, the MIC range was 0.25 to 1 microg/ml, and the MIC at which 50% of the isolates tested are inhibited (MIC50) and the MIC90 were 0.5 and 1 microg/ml, respectively. The geometric mean 48-h MIC of itracona...
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Breslau, Abraham M. (Veterans Administration Center and University of California Los Angeles Center for the Health Sciences, Los Angeles, Calif.), and Mike Y. Kubota. Continuous in vitro cultivation of spherules of Coccidioides immitis. J. Bacteriol. 87:468-472. 1964.-Spherules of Coccidioides immitis were grown in vitro in continuous culture for more than 4 years. Cultures were grown in modifi...
متن کاملPolysaccharide of Coccidioides immitis.
Pappagianis, D. (University of California, Berkeley), E. W. Putman, and G. S. Kobayashi. Polysaccharide of Coccidioides immitis. J. Bacteriol. 82:714-723. 1961.-Soluble polysaccharide from mycelia or culture filtrates of Coccidioides immitis was found to consist mainly of mannose, but also included small quantities of galactose and another reducing sugar. Isolation of the polysaccharide by etha...
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2015
ISSN: 2328-8957
DOI: 10.1093/ofid/ofv133.506